With the Python 3.6 Beta version there is a Flask included.
This seems to be working. I have tried this with a small app that reads and displays codepages.
Only thing that is that it draws a lot of CPU when run with app.debug=True. This may be a Flask problem that may be fixed with watchdog package or with a z/OS specific solution for monitoring changes in the file system.
With debug=False it is better in CPU consumption, but for production a solid web server should be used (e.g Apache with mod_wsgi). Tornado is included in the package as well that could be used to serve a WSGI Flask app