There are several different operation codes available with the EXTFH file handler for doing random reads on an indexed file.

8E	READ (random) WITH NO LOCK	R I
DA	READ (random) WITH LOCK	R I
DB	READ (random) WITH KEPT LOCK	R I
F6	READ (random)	R I

What is the difference between F6 READ (random) and 8E READ (random ) WITH NO LOCK?

The difference comes down to the lock mode that is set on for the file.

FhOp-Read-Random-No-Lock value x'8E' will always read a record without obtaining a lock for it, regardless of the lock mode used.

FhOp-Read-Random value x'F6' will either lock a record when read or not lock a record when read depending on the lock mode used in the open.

If lock mode automatic is set, then FhOp-Read-Random will lock the record.
If lock mode manual is set, then FhOp-Read-Random will not lock the record.

fcd-lock-mode pic x comp-x Lock mode flags for shareable files:
Bit 7 - Lock on multiple records
Bit 6 - WRITELOCK directive enabled
Bit 5 - RETRYOPEN=ON
Bit 4 - SKIPLOCK =ON
Bit 3 - RETRYLOCK=ON
Bit 2 - Lock mode MANUAL
Bit 1 - Lock mode AUTOMATIC
Bit 0 - Lock mode EXCLUSIVE