Do you have an example use case to shed further light as to what you are asking for? The Changeman ZMF plugin for Zowe Cli provides the ability to call ZMF Rest API's using python scripting.
We have no experience of managing mainframe Python as we have no access to that implementation of Python.
Personally, I use ZMF to secure Python code which I develop for use off mainframe (i.e. it is coded/tested/used off-mainframe I just use ZMF to save versions of the code at certain checkpoints in development).
However, that is simply using zFS libtypes to secure versions of non-mainframe Python code (I use gitZMF to send to/from the package).
I have no ‘deployment’ mechanisms as the code is never used on the mainframe.
If there are specific deployment mechanisms required for mainframe Python, other than just copying it to a different location, then we would need to find out more about those, we know nothing about them at the moment.
The standard promote/install/etc copy processes will work as expected.